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What is beef knuckle? Beef knuckle is a very versatile cut of meat, which comes from the rear of an animal. Beef deli knuckle is most well-known for being used in sirloin tip roast and many other meat dishes. Slow cook or roast a cut of beef knuckle and enjoy its tenderness and flavor. Choose from herbs and spices, chicken, and seafood. If you're wondering where to buy deli knuckle in bulk, we have a large selection of beef knuckle for sale at the lowest prices.