Mezcal Margarita

Maybe your tequila tastings have been a success and you want to expand your menu, or maybe you’re getting ready to celebrate Hispanic Heritage Month and are looking for recipes to use. Whatever the case may be, check out our mezcal margarita recipe below.

Mezcal Margarita Recipe Video

Watch our video below on how to make this mezcal margarita recipe!

Spicy Grapefruit Mezcal Margarita Recipe

Mezcal Margaritas

Yield: 2 servings

Total Time: 5 minutes


  • 1 Tablespoon Tajin
  • 4 ounces mezcal
  • 1 grapefruit, juiced
  • 1 teaspoon of honey
  • 1 small jalapeno pepper, deseeded and thinly sliced into rounds
  • 2 limes, juiced
  • 1 lime, cut into quarters
  • Ice cubes
  • Dried fruit for garnish (optional)
  • Edible flowers for garnish (optional)


  1. Pour Tajin on small plate.
  2. Fill cocktail shaker with ice cubes.
  3. Pour mezcal into cocktail shaker, along with grapefruit juice, honey, 4-6 jalapeno slices, and lime juice.
  4. Replace lid of cocktail shaker and shake for 30 seconds.
  5. Grab two margarita glasses and line half the rim and side of each glass with lime juice from one lime quarter.
  6. Gently roll lime-juiced side of glass into Tajin.
  7. Add fresh ice cubes to each glass.
  8. Evenly pour mezcal margarita mixture into each glass.
  9. Optionally, garnish each glass with a few jalapeno slices, a lime quarter or dried fruit, and an edible flower.

Mezcal FAQ

Mezcal Margaritas, Agave

Mezcal is finally growing in popularity in America. Here are a few frequently asked questions that we have answered for you:

What Is the Difference Between Mezcal and Tequila?

The difference between mezcal and tequila is that mezcal can be made with any type of agave, whereas tequila is only made from blue agave. Therefore, all tequilas are a type of mezcal, but not all mezcals are tequila. This is the same as bourbon being a type of whiskey, but not all whiskey is bourbon.

Mezcal also has a smoky flavor whereas tequila is smoother thanks to its terroir.

Is Mezcal Stronger Than Tequila?

Yes, mezcal is stronger than tequila. Mezcal has an alcohol by volume (ABV) of 55%, while tequila is only at 40%.

Can You Substitute Mezcal for Tequila in a Margarita?

Yes, you can substitute mezcal for tequila (and vice versa) in margaritas or any cocktails. Just know that mezcal has a higher ABV and smokier flavor than tequila.

Is Mezcal Tequila Good for Margaritas?

Yes, mezcal is great for margaritas! Mezcal pairs especially well with jalapenos, hibiscus, tropical fruits like mangoes and pineapple, and citrus fruits like grapefruits, oranges, and limes.

Whether it’s for a pairing with a tapas menu or for a summer cocktail menu, this mezcal margarita recipe is going to be a hit. Best of all, it’s easy to scale up to make a pitcher, or scale down to make a single glass!

Posted in: Bars & Breweries|Recipes|By Val Goodrich
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